AL

Andrey Leskov

24 articles

Author's articles

Diamox in the mountains: higher oxygen saturation, but 32% less time to exhaustion

Diamox in the mountains: higher oxygen saturation, but 32% less time to exhaustion

Acetazolamide (Diamox; sold in Russia as Diakarb) is what people pack for Elbrus and high-altitude trail races to keep altitude sickness at bay. A double-blind study from October 2026 showed the flip side: at a simulated 3800 metres, a preventive dose raised oxygen saturation but cut time to exhaustion from 365 to 250 seconds. We look at why this happens, what older studies say and where doping control comes in.

Andrey Leskovβ€’
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Paraxanthine instead of caffeine: what 14 rowers and 12 runners revealed about the β€œclean stimulant” made from a coffee metabolite

Paraxanthine instead of caffeine: what 14 rowers and 12 runners revealed about the β€œclean stimulant” made from a coffee metabolite

The liver turns about 70% of caffeine into paraxanthine, and now it is sold on its own β€” as a stimulant without the insomnia and jitters. In a 2026 RCT in rowers, paraxanthine by itself did not speed up a 2000 m test, and in a 2024 study of a 10 km run it did not change finishing time at all. It disrupted sleep after an evening session less β€” but that was measured with a questionnaire.

Andrey Leskovβ€’
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